| Data | Time da casa | Placar | Time Visitante | Estádio | Status |
|---|---|---|---|---|---|
| 16/08/2010 | Manchester United | 3 - 0 | Newcastle United | Old Trafford | Final |
| 22/08/2010 | Fulham | 2 - 2 | Manchester United | Craven Cottage | Final |
| 28/08/2010 | Manchester United | 3 - 0 | West Ham United | Old Trafford | Final |
| 11/09/2010 | Everton | 3 - 3 | Manchester United | Goodison Park | Final |
| 19/09/2010 | Manchester United | 3 - 2 | Liverpool | Old Trafford | Final |
| 26/09/2010 | Bolton Wanderers | 2 - 2 | Manchester United | Reebok Stadium | Final |
| 02/10/2010 | Sunderland | 0 - 0 | Manchester United | Stadium of Light | Final |
| 16/10/2010 | Manchester United | 2 - 2 | West Bromwich Albion | Old Trafford | Final |
| 24/10/2010 | Stoke City | 1 - 2 | Manchester United | Britannia Stadium | Final |
| 30/10/2010 | Manchester United | 2 - 0 | Tottenham | Old Trafford | Final |
| 06/11/2010 | Manchester United | 2 - 1 | Wolverhampton | Old Trafford | Final |
| 10/11/2010 | Manchester City | 0 - 0 | Manchester United | City of Manchester Stadium | Final |
| 13/11/2010 | Aston Villa | 2 - 2 | Manchester United | Villa Park | Final |
| 20/11/2010 | Manchester United | 2 - 0 | Wigan Athletic | Old Trafford | Final |
| 27/11/2010 | Manchester United | 7 - 1 | Blackburn Rovers | Old Trafford | Final |
| 13/12/2010 | Manchester United | 1 - 0 | Old Trafford | Final | |
| 26/12/2010 | Manchester United | 2 - 0 | Sunderland | Old Trafford | Final |
| 28/12/2010 | Birmingham City | 1 - 1 | Manchester United | St Andrews Stadium | Final |
| 01/01/2011 | West Bromwich Albion | 1 - 2 | Manchester United | The Hawthorns | Final |
| 04/01/2011 | Manchester United | 2 - 1 | Stoke City | Old Trafford | Final |
| 16/01/2011 | Tottenham | 0 - 0 | Manchester United | White Hart Lane | Final |
| 22/01/2011 | Manchester United | 5 - 0 | Birmingham City | Old Trafford | Final |
| 25/01/2011 | Blackpool | 2 - 3 | Manchester United | Bloomfield Road | Final |
| 01/02/2011 | Manchester United | 3 - 1 | Aston Villa | Old Trafford | Final |
| 05/02/2011 | Wolverhampton | 2 - 1 | Manchester United | Molineux Stadium | Final |
| 12/02/2011 | Manchester United | 2 - 1 | Manchester City | Old Trafford | Final |
| 26/02/2011 | Wigan Athletic | 0 - 4 | Manchester United | The DW Stadium | Final |
| 01/03/2011 | Chelsea | 2 - 1 | Manchester United | Stamford Bridge | Final |
| 06/03/2011 | Liverpool | 3 - 1 | Manchester United | Anfield | Final |
| 19/03/2011 | Manchester United | 1 - 0 | Bolton Wanderers | Old Trafford | Final |
| 02/04/2011 | West Ham United | 2 - 4 | Manchester United | Upton Park | Final |
| 09/04/2011 | Manchester United | 2 - 0 | Fulham | Old Trafford | Final |
| 19/04/2011 | Newcastle United | 0 - 0 | Manchester United | St James Park | Final |
| 23/04/2011 | Manchester United | 1 - 0 | Everton | Old Trafford | Final |
| 01/05/2011 | 1 - 0 | Manchester United | Emirates Stadium | Final | |
| 08/05/2011 | Manchester United | 2 - 1 | Chelsea | Old Trafford | Final |
| 14/05/2011 | Blackburn Rovers | vs. | Manchester United | Ewood Park | 4:45 |
| 22/05/2011 | Manchester United | vs. | Blackpool | Old Trafford | 8:00 |
| Pos. | Time | J | V | E | D | PTS |
|---|---|---|---|---|---|---|
| 1 | Manchester City | 38 | 28 | 5 | 5 | 89 |
| 2 | Manchester United | 38 | 28 | 5 | 5 | 89 |
| 3 | 38 | 21 | 7 | 10 | 70 | |
| 4 | Tottenham | 38 | 20 | 9 | 9 | 69 |
| 5 | Newcastle United | 38 | 19 | 8 | 11 | 65 |
| 6 | Chelsea | 38 | 18 | 10 | 10 | 64 |
| 7 | Everton | 38 | 15 | 11 | 12 | 56 |
| 8 | Liverpool | 38 | 14 | 10 | 14 | 52 |
| 9 | Fulham | 38 | 14 | 10 | 14 | 52 |
| 10 | West Bromwich Albion | 38 | 13 | 8 | 17 | 47 |
| 11 | 38 | 12 | 11 | 15 | 47 | |
| 12 | 38 | 12 | 11 | 15 | 47 | |
| 13 | Sunderland | 38 | 11 | 12 | 15 | 45 |
| 14 | Stoke City | 38 | 11 | 12 | 15 | 45 |
| 15 | Wigan Athletic | 38 | 11 | 10 | 17 | 43 |
| 16 | Aston Villa | 38 | 7 | 17 | 14 | 38 |
| 17 | 38 | 10 | 7 | 21 | 37 | |
| 18 | Birmingham City | 37 | 8 | 15 | 14 | 39 |
| 18 | Bolton Wanderers | 38 | 10 | 6 | 22 | 36 |
| 19 | Blackburn Rovers | 38 | 8 | 7 | 23 | 31 |
| 19 | Blackpool | 37 | 10 | 9 | 18 | 39 |
| 20 | West Ham United | 37 | 7 | 12 | 18 | 33 |
| 20 | Wolverhampton | 38 | 5 | 10 | 23 | 25 |